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spice, k2, jwh and other cannibinoids created synthetically to mimic natural ones are untested in humans. You are essentially being a guinea pig by ingesting such products because the long term effects are unknown.
Do some googling. Its all there if you look for it.
Although, i dont really know why you are looking for all this, given that you have previous questions that suggestion you are strongly opposed to drug use.
And its clear you are pretty uneducated about all this. Three of those that you mention are essentially the same thing, and they are all made to imitate the effects of the fourth, and do so quite well.
And none of the things you mentioned would be a problem for anyone if they would just legalize marijuana. The whole reason marijuana subsitutes come out is because marijuana is illegal. Our gov acts like the drug nazi unless its a drug that lines their pockets with cash, like tobacco and alcohol… those two are worse than many illegal drugs, but are soooo protected today, even despite public smoking bans.